Tau profiling across Alzheimer's disease staging reveals vulnerability to disease pathophysiology.

Background: Inter-individual variability in tau topography challenges the propagation hypothesis of tau aggregates. Methods: To address this gap, we propose the Manifold Component Analysis (MCA), for identifying pseudo-continuous profiles informed by the spatial continuity of stage regions. Results:...

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Publicado en:	European Journal of Nuclear Medicine & Molecular Imaging Vol. 52; no. 11; pp. 4281 - 4292
Autores principales:	Bezgin, Gleb, Pascoal, Tharick A., Therriault, Joseph, Lussier, Firoza Z., Servaes, Stijn, Kang, Min Su, Savard, Mélissa, Tissot, Cécile, Stevenson, Jenna, Wang, Yi-Ting, Ottoy, Julie, Rahmouni, Nesrine, Fernandez-Arias, Jaime, Hosseini, Seyyed Ali, Aumont, Étienne, Hall, Brandon, Poltronetti, Nina Margherita, Pallen, Vanessa, Benedet, Andréa Lessa, Ashton, Nicholas J.
Formato:	Journal Article
Publicado:	Springer Nature Sep2025
Acceso en línea:	Ver este registro en EBSCOhost