| Sumario: | Background: We evaluated the impact of noninvasive respiratory support (NRS) and invasive mechanical ventilation duration before venovenous extracorporeal membrane oxygenation (VV-ECMO) on weaning from venovenous ECMO and survival. Methods: In a retrospective single-center study, we studied subjects with COVID-19 ARDS treated with VV-ECMO. The subjects were divided and analyzed according to the cut-off of NRS, invasive ventilation, and total duration of respiratory support. Results: We identified a cut-off of NRS duration of 4 days, invasive ventilation duration of 5 days, and total respiratory support duration of 8 days. Weaning from VV-ECMO was observed in 63% (15/24) of subjects with NRS duration ≤ 4 days and in 16% (4/25) of subjects with NRS > 4 days (P =.001), in 50% (17/34) of subjects with invasive ventilation duration ≤ 5 days, in 13% (2/15) of subjects with invasive ventilation duration > 5 days (P =.02), in 68% (13/19) of subjects with total support duration < 8 days, and in 20% (6/30) of subjects with total support duration > 8 days (P =.001). The survival probability at 200 days demonstrated a statistically significant difference in NRS and total support duration comparison (P =.001 and P =.004, respectively). We did not find a statistically significant survival difference according to invasive ventilation duration (P =.13). Conclusions: In our population, the increase in NRS and total support days before ECMO could hamper weaning from VV-ECMO support. However, due to the pandemic, the small sample size, and the lack of precise data on ventilation settings, caution should be exercised in universalizing these results.
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