Effect of Respiratory Support Type and Total Duration on Weaning From Venovenous Extracorporeal Membrane Oxygenation in COVID-19 Patients.
Background: We evaluated the impact of noninvasive respiratory support (NRS) and invasive mechanical ventilation duration before venovenous extracorporeal membrane oxygenation (VV-ECMO) on weaning from venovenous ECMO and survival. Methods: In a retrospective single-center study, we studied subjects...
| Publicado en: | Respiratory Care Vol. 70; no. 9; pp. 1140 - 1148 |
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| Autores principales: | , , , , , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Mary Ann Liebert, Inc.
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187691958&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187691958 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00201324 4GG jtl: Respiratory Care issn: 00201324 maglogo: N pubinfo: dt: Sep2025 vid: 70 iid: 9 pid: 1365 pub: Mary Ann Liebert, Inc. place: New Rochelle, New York artinfo: ui: 187691958 187691958 187691958 10.1089/respcare.12246 187691958 ppf: 1140 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Effect of Respiratory Support Type and Total Duration on Weaning From Venovenous Extracorporeal Membrane Oxygenation in COVID-19 Patients. aug: au: Marabotti, Alberto Cianchi, Giovanni Pelagatti, Filippo Ciapetti, Marco Franci, Andrea Socci, Filippo Fulceri, Giorgio Enzo Lazzeri, Chiara Bonizzoli, Manuela Peris, Adriano affil: Drs. Marabotti, Cianchi, Ciapetti, Franci, Socci, Fulceri, Lazzeri, Bonizzoli, and Peris are affiliated with Intensive Care Unit and Regional ECMO Referral Centre, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy. sug: subj: Extracorporeal Membrane Oxygenation COVID-19 Psychosocial Factors Respiratory Distress Syndrome, Acute Invasive Procedures Noninvasive Procedures Respiration, Artificial Treatment Outcomes Human Male Female Adult Middle Age Retrospective Design Record Review ROC Curve T-Tests Mann-Whitney U Test Financial Information Systems Fisher's Exact Test Survival Analysis Adult: 19-44 years Middle Aged: 45-64 years Male Female ab: Background: We evaluated the impact of noninvasive respiratory support (NRS) and invasive mechanical ventilation duration before venovenous extracorporeal membrane oxygenation (VV-ECMO) on weaning from venovenous ECMO and survival. Methods: In a retrospective single-center study, we studied subjects with COVID-19 ARDS treated with VV-ECMO. The subjects were divided and analyzed according to the cut-off of NRS, invasive ventilation, and total duration of respiratory support. Results: We identified a cut-off of NRS duration of 4 days, invasive ventilation duration of 5 days, and total respiratory support duration of 8 days. Weaning from VV-ECMO was observed in 63% (15/24) of subjects with NRS duration ≤ 4 days and in 16% (4/25) of subjects with NRS > 4 days (P =.001), in 50% (17/34) of subjects with invasive ventilation duration ≤ 5 days, in 13% (2/15) of subjects with invasive ventilation duration > 5 days (P =.02), in 68% (13/19) of subjects with total support duration < 8 days, and in 20% (6/30) of subjects with total support duration > 8 days (P =.001). The survival probability at 200 days demonstrated a statistically significant difference in NRS and total support duration comparison (P =.001 and P =.004, respectively). We did not find a statistically significant survival difference according to invasive ventilation duration (P =.13). Conclusions: In our population, the increase in NRS and total support days before ECMO could hamper weaning from VV-ECMO support. However, due to the pandemic, the small sample size, and the lack of precise data on ventilation settings, caution should be exercised in universalizing these results. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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