The interaction between chronic heart failure and nervous system and its implication for treatment for brain and heart.
Chronic heart failure (CHF) is a complex syndrome, one of whose pathophysiological features is the abnormal activation of the neurohumoral system, especially the excessive excitation of the sympathetic nerve and the continuous activation of the renin-angiotensin-aldosterone system (RAAS). At the sam...
| Publicado en: | Chinese Journal of Contemporary Neurology & Neurosurgery Vol. 25; no. 8; pp. 732 - 739 |
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| Autores principales: | , , |
| Formato: | review Journal Article |
| Publicado: |
Chinese Journal of Contemporary Neurology & Neurosurgery
Aug2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=187822210&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 187822210 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 16726731 FDQ6 jtl: Chinese Journal of Contemporary Neurology & Neurosurgery issn: 16726731 maglogo: N pubinfo: dt: Aug2025 vid: 25 iid: 8 pid: 80951 pub: Chinese Journal of Contemporary Neurology & Neurosurgery artinfo: ui: 187822210 187822210 187822210 10.3969/j.issn.1672-6731.2025.08.008 187822210 ppf: 732 ppct: 7 formats: fmt: @attributes: type: P tig: atl: The interaction between chronic heart failure and nervous system and its implication for treatment for brain and heart. aug: au: LI, Meng-qi DU, Yong TIAN, Yi-kui affil: Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China sug: subj: Heart Failure Physiopathology Nervous System Diseases Physiopathology Heart Failure Therapy Nervous System Diseases Therapy Health Care Delivery, Integrated Patient Care Methods Cardiovascular System Physiology Autonomic Nervous System Physiopathology Cognition Disorders Body Fluids Renin-Angiotensin System Brain Physiopathology Cognition Neural Pathways Cardiac Output Baroreflex Neuroinflammation Oxidative Stress Apoptosis Fibrosis Ventricular Remodeling Enalapril Therapeutic Use Valsartan Therapeutic Use Dapagliflozin Therapeutic Use Vagal Stimulation Cardiac Resynchronization Therapy Biological Markers Treatment Outcomes ab: Chronic heart failure (CHF) is a complex syndrome, one of whose pathophysiological features is the abnormal activation of the neurohumoral system, especially the excessive excitation of the sympathetic nerve and the continuous activation of the renin-angiotensin-aldosterone system (RAAS). At the same time, the decreased cardiac output caused by chronic heart failure can lead to cerebral hypoperfusion and significantly affect cognitive function; conversely, cognitive impairment caused by cerebral hypoperfusion could exacerbate cardiac dysfunction, suggesting a close bidirectional regulatory relationship between the heart and the brain. This article aims to systematically explore the mutual influence-mechanism between chronic heart failure and the nervous system, elaborating on its pathophysiological basis from multiple dimensions such as the regulation of cardiovascular function by neurohumoral regulation under physiological conditions, the pathological mechanism of autonomic nerve imbalance, neurohumoral disorder and dysfunction of neuro-compensation mechanism during the development of chronic heart failure, and the damage of chronic heart failure to cognitive function, and providing theoretical support and practical guidance for the clinical realization of treatment for brain and heart. pubtype: Academic Journal doctype: review Journal Article ougenre: Article language: Chinese refInfo: holdings: @attributes: islocal: N |
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