| Summary: | Background: Frequent premature ventricular complexes (PVC) can lead to left ventricular (LV) dysfunction. Reduction of PVC burden can result in improvement of LV function. Whether successful PVC ablation can also result in improvement of mitral regurgitation (MR) in patients with frequent PVCs and MR remains unclear. Objective: We aimed to evaluate the impact of PVC ablation on the degree of MR in patients with patients with frequent PVCs and MR. Method: We retrospectively analyzed patients with MR and frequent PVCs who underwent PVC ablation from January 2015 to December 2024. Severity of MR was compared between pre‐ and post‐PVC ablation to identify improvement of valvular regurgitation. Results: A total of 47 patients were included in the study. All patients had at least mild MR (6 with mild MR, 17 mild‐moderate MR, 19 moderate MR, 3 moderate‐severe MR, and 2 severe MR). The mean PVC burdens before versus after ablation were 23.5 ± 11% and 4 ± 4.1% (p = 0.02), respectively. Improvement (by ≥ 1 grade) of MR was seen in 30 of 47 (64%) patients after ablation. Among patients with > 80% PVC reduction after ablation, 19 of 29 (65.5%), 50%–80% PVC reduction, 9 of 13 (69%), and < 50% PVC reduction, 2 of 5 (40%) showed improvement of MR. All 5 of (100%) patients with greater than moderate MR demonstrated an improvement in MR severity after PVC ablation. Conclusion: There appears to be a trend toward an MR improvement with reduction in PVC burden after successful PVC ablation.
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