| Sumario: | Aims Alcohol consumption is associated with numerous detrimental health outcomes and aging-related disorders. This study aims to investigate the impact of alcohol drinking levels and drinking behavior on serum levels of Klotho protein, an anti-aging biomarker for health and longevity, in middle-aged and older adults. Methods A nationally representative sample of 4225 adults aged 40–79 years from the 2013–2016 National Health and Nutrition Examination Surveys were analyzed using multiple general linear models. Drinking levels were classified as light (consumed ≤ 2 drinks for men and ≤ 1 drink for women in a day), moderate (3–4 for men and 2–3 drinks for women), and heavy drinking (≥ 5 for men and ≥ 4 drinks for women), according to national guidelines. Results Significantly decreased serum ɑ-Klotho levels were found in all levels of drinking in a dose-dependent manner, with weighted geometric means of 798.80 (P = .0238), 774.75 (P = .0006), 751.83 (P = .0027), and 744.33 pg/ml (P < .0001) in light, moderate, heavy, and former heavy drinkers, respectively, compared to non-drinkers (827.69 pg/ml). After adjusting for covariates, moderate drinking was associated with a 6.53% (P < .0001) decrease, heavy drinking with an 8.97% (P = .0004) decrease, and former heavy drinking with an 7.26% (P < .0001) decrease in ɑ-Klotho levels. Similarly, binge drinking ≥ 4 days in the past month was associated with a 9.17% (P = .0341) decrease in serum ɑ-Klotho. Conclusions This study demonstrates a significantly inverse relationship between alcohol consumption and serum ɑ-Klotho levels in middle-aged and older adults. Further studies are warranted to elucidate the role of reducing Klotho levels in alcohol-induced health and aging disorders.
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