Decreases in serum α-Klotho levels in association with levels of regular alcohol drinking and binge drinking among US adults.
Aims Alcohol consumption is associated with numerous detrimental health outcomes and aging-related disorders. This study aims to investigate the impact of alcohol drinking levels and drinking behavior on serum levels of Klotho protein, an anti-aging biomarker for health and longevity, in middle-aged...
| Publicado en: | Alcohol & Alcoholism Vol. 60; no. 5; pp. 1 - 8 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Oxford University Press / USA
Sep2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188121936&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188121936 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 07350414 FA3 jtl: Alcohol & Alcoholism issn: 07350414 maglogo: N pubinfo: dt: Sep2025 vid: 60 iid: 5 pid: 622 pub: Oxford University Press / USA artinfo: ui: 188121936 188121936 188121936 10.1093/alcalc/agaf054 188121936 ppf: 1 ppct: 7 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Decreases in serum α-Klotho levels in association with levels of regular alcohol drinking and binge drinking among US adults. aug: au: Fromm, Dylan Zhu, Jianmin Kim, Wonjun Billy Wei, Yudan affil: MD Program, Mercer University School of Medicine, 1501 Mercer University Dr., Macon, GA 31207, United States sug: subj: Alcohol Drinking In Adulthood Binge Drinking In Adulthood Klotho Proteins Blood Aging Biological Markers Blood Health Status Longevity Human Male Female Adult Middle Age Aged United States Cross Sectional Studies Surveys Alcoholism Oxidative Stress Multiple Linear Regression Binge Drinking Epidemiology Mortality Risk Factors Risk Assessment Health Screening Questionnaires Enzyme-Linked Immunosorbent Assay Methods Descriptive Statistics Comparative Studies Data Analysis Software Probability Sample Analysis of Variance Adult: 19-44 years Middle Aged: 45-64 years Aged: 65+ years Male Female ab: Aims Alcohol consumption is associated with numerous detrimental health outcomes and aging-related disorders. This study aims to investigate the impact of alcohol drinking levels and drinking behavior on serum levels of Klotho protein, an anti-aging biomarker for health and longevity, in middle-aged and older adults. Methods A nationally representative sample of 4225 adults aged 40–79 years from the 2013–2016 National Health and Nutrition Examination Surveys were analyzed using multiple general linear models. Drinking levels were classified as light (consumed ≤ 2 drinks for men and ≤ 1 drink for women in a day), moderate (3–4 for men and 2–3 drinks for women), and heavy drinking (≥ 5 for men and ≥ 4 drinks for women), according to national guidelines. Results Significantly decreased serum ɑ-Klotho levels were found in all levels of drinking in a dose-dependent manner, with weighted geometric means of 798.80 (P = .0238), 774.75 (P = .0006), 751.83 (P = .0027), and 744.33 pg/ml (P < .0001) in light, moderate, heavy, and former heavy drinkers, respectively, compared to non-drinkers (827.69 pg/ml). After adjusting for covariates, moderate drinking was associated with a 6.53% (P < .0001) decrease, heavy drinking with an 8.97% (P = .0004) decrease, and former heavy drinking with an 7.26% (P < .0001) decrease in ɑ-Klotho levels. Similarly, binge drinking ≥ 4 days in the past month was associated with a 9.17% (P = .0341) decrease in serum ɑ-Klotho. Conclusions This study demonstrates a significantly inverse relationship between alcohol consumption and serum ɑ-Klotho levels in middle-aged and older adults. Further studies are warranted to elucidate the role of reducing Klotho levels in alcohol-induced health and aging disorders. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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