Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 "nodules in nodule".
Objectives: To explore the associations between the apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 "nodules in nodule" and their pathological characteristics. Methods: We retrospectively analyzed the prostate images from 226 male patients who underwent biopsy followi...
| Publicado en: | Abdominal Radiology Vol. 50; no. 11; pp. 5292 - 5305 |
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| Autores principales: | , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Springer Nature
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=188951995&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 188951995 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 2366004X JT14 jtl: Abdominal Radiology issn: 2366004X maglogo: N pubinfo: dt: Nov2025 vid: 50 iid: 11 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 188951995 184781936 10.1007/s00261-025-04930-y 188951995 ppf: 5292 ppct: 13 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Diagnostic performance of apparent diffusion coefficient values in differentiating benign from malignant lesions in prostate PI-RADS v2.1 category 1 "nodules in nodule". aug: au: Sun, Minghua Li, Fei Zhang, Xiaoyan Wu, Rui Liu, Wenya Xu, Li Wu, Mengjie Wang, Yangang affil: https://ror.org/03xb04968 Department of Radiology, The Fuyang Hospital Of Anhui Medical University, No. 99, Mount Huangshan Road, Fuhe Modern Industrial Park, Yingzhou District, 236000, Fuyang, Anhui Province, China sug: ab: Objectives: To explore the associations between the apparent diffusion coefficient (ADC) values of prostate PI-RADS v2.1 category 1 "nodules in nodule" and their pathological characteristics. Methods: We retrospectively analyzed the prostate images from 226 male patients who underwent biopsy following MRI from January 2019 to December 2024. Two radiologists evaluated the PI-RADS v2.1 categories of identified nodules, measured the ADC values of the prostate nodules in a double-blind manner, and analyzed the associations between these values and the pathological characteristics of the nodules via independent sample t tests or Mann-Whitney U test. Results: The ADC values of PI-RADS v2.1 category 1 "nodules in nodule" pathologically confirmed as clinically significant prostate cancer (csPCa) were lower than those of benign prostate hyperplasia (BPH) ((unit in ×10− 3 mm2/s)TZ: 0.739 ± 0.15 versus 0.984 ± 0.24; PZ: 0.719 ± 0.17 versus 1.036 ± 0.21, p < 0.001). The AUCs were 0.799 (TZ) with a cutoff of 0.835 × 10− 3mm2/s, and 0.873(PZ) with a cutoff of 0.795 × 10− 3mm2/s, respectively. The total prostate-specific antigen (tPSA), free/t PSA, PSA density (PSAD), and prostate gland volume (PGV) differed significantly between patients with PI-RADS v2.1 "nodules in nodule" that were pathologically confirmed as csPCa and patients with BPH (all p < 0.05). Conclusion: In patients with PI-RADS v2.1 category 1 "nodules in nodule", when the ADC values are less than 0.835 × 10− 3mm2/s in the TZ, the PI-RADS v2.1 score of the nodule can be upgraded to 3. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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