Effect of a multiphase dietary intervention on metabolic profile and gut microbiota composition in metabolically healthy and unhealthy obese subjects.
Gut microbiota influences obesity and its comorbidities by affecting metabolism and inflammation. The metabolic phenotype of obese individuals alters microbiota composition and metabolite production, impacting metabolic risk. This study examined the effects of a multiphase dietary intervention on me...
| Publicado en: | Clinical Nutrition Vol. 54; pp. 62 - 71 |
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| Autores principales: | , , , , , , , , |
| Formato: | clinical trial research Journal Article |
| Publicado: |
Elsevier B.V.
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189076076&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189076076 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 02615614 8IC jtl: Clinical Nutrition issn: 02615614 maglogo: N pubinfo: dt: Nov2025 vid: 54 pid: 467 pub: Elsevier B.V. place: New York, New York artinfo: ui: 189076076 189076076 189076076 10.1016/j.clnu.2025.09.010 189076076 ppf: 62 ppct: 9 formats: tig: atl: Effect of a multiphase dietary intervention on metabolic profile and gut microbiota composition in metabolically healthy and unhealthy obese subjects. aug: au: Bosch-Sierra, N. Navajas-Porras, B. Grau-del Valle, C. Salom, C. Pérez-Burillo, S. D'Auria, G. Francino, M.P. Morillas, C. Bañuls, C. affil: Department of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia 46017, Spain sug: subj: Obesity Diet Therapy Metabolic Syndrome X Diet Therapy Diet, Reducing Inflammation Metabolism Evaluation Gut Microbiota Analysis Treatment Outcomes Human Clinical Trials Feces Microbiology Metabolites Phenotype Descriptive Statistics Male Female Weight Loss Acetic Acid Blood Insulin Resistance Blood Pressure Adipose Tissue Distribution Male Female ab: Gut microbiota influences obesity and its comorbidities by affecting metabolism and inflammation. The metabolic phenotype of obese individuals alters microbiota composition and metabolite production, impacting metabolic risk. This study examined the effects of a multiphase dietary intervention on metabolism, inflammation, and gut microbiota diversity in obese individuals with and without metabolic syndrome (MetS). The current interventional study describes differences in faecal microbial composition and serum metabolite signatures between two obese phenotypes (with versus without MetS) after a 6-month multiphase dietary intervention (consisting of two six-week phases of very-low calorie diet, separated by a 3-month hypocaloric diet) in 109 participants (64 % women). We found that weight loss improved gut microbiota diversity and composition, and was more effective in participants with MetS. Furthermore, only the MetS group showed a significant improvement in serum levels of acetate and a decrease for trimethylamine. In addition, strong correlations were observed between gut microbiota and clinical parameters, including insulin resistance, blood pressure, and visceral fat. These results demonstrate that populations with obesity can respond differently to the same dietary intervention according to their metabolic phenotype, a difference manifested in gut microbiota parameters. Furthermore, the positive impact of multiphase dietary intervention on microbiota serum metabolites and microbiota composition is more pronounced in obese individuals with MetS. pubtype: Academic Journal doctype: clinical trial research Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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