Comparison of HMGB1, RAGE, TLR4, and NF-κB levels in children and adolescents diagnosed with autism spectrum disorder with healthy controls.
Introduction: The objective of our study is to clarify the involvement of the HMGB1/RAGE/TLR4/NF-kB axis, a crucial component in inflammation, in the etiopathogenesis of autism spectrum disorder (ASD). Method: We analyzed the levels of HMGB1, RAGE, TLR4, and NF-kB in serum from 80 children (40 with...
| Publicado en: | International Journal of Developmental Disabilities Vol. 71; no. 7; pp. 1073 - 1081 |
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| Autores principales: | , , , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Nov2025
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=189365398&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 189365398 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20473869 F2SP jtl: International Journal of Developmental Disabilities issn: 20473869 maglogo: N pubinfo: dt: Nov2025 vid: 71 iid: 7 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 189365398 174746908 189365398 189365398 10.1080/20473869.2023.2301185 189365398 ppf: 1073 ppct: 8 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Comparison of HMGB1, RAGE, TLR4, and NF-κB levels in children and adolescents diagnosed with autism spectrum disorder with healthy controls. aug: au: Kıyat, Esra Aktepe, Evrim Kumbul Doğuç, Duygu Bedir, Mehmet Ertürk, Emre Işık, Ümit affil: Department of Child and Adolescent Psychiatry, Süleyman Demirel University Faculty of Medicine, Isparta, Turkey sug: subj: Autism Spectrum Disorder Pathology Autism Spectrum Disorder Pathology Alarmins Blood Glycation End Products, Advanced Blood Toll-Like Receptors Blood NF-kappa B Blood Inflammation Risk Assessment Human Sociodemographic Factors Severity of Illness Checklists Scales Adolescence Funding Source Male Female Infant Child, Preschool Child Data Analysis Software Mann-Whitney U Test Chi Square Test Spearman's Rank Correlation Coefficient Adolescent: 13-18 years Infant: 1-23 months Child, Preschool: 2-5 years Child: 6-12 years Male Female ab: Introduction: The objective of our study is to clarify the involvement of the HMGB1/RAGE/TLR4/NF-kB axis, a crucial component in inflammation, in the etiopathogenesis of autism spectrum disorder (ASD). Method: We analyzed the levels of HMGB1, RAGE, TLR4, and NF-kB in serum from 80 children (40 with ASD and 40 controls). All participants' sociodemographic characteristics were recorded. In order to determine the severity of the disorder, the Aberrant Behavior Checklist, Childhood Autism Rating Scale, and Autism Behavior Checklist were administered to the ASD group. Result: While the soluble TLR4 level was significantly higher in the ASD group (p < 0.001), other parameters examined did not show significant differences between groups. Furthermore, soluble TLR4 serum level was positively correlated with Problem Behavior Checklist hyperactivity subscale scores (p = 0.031), and RAGE serum level was negatively correlated with ABC Stereotype score (p = 0.001). Discussion: It was thought that serum TLR4 levels may be important in the etiology of ASD. TLR4 levels are linked to symptoms like hyperactivity in autism, which suggests that this parameter could be used as a clinical guide. Further research is required to substantiate our discoveries and to clarify the involvement of HMGB1, RAGE, TLR4, and NF-kB in the etiopathogenesis of ASD. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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