Investigating the effects of applying low acoustic frequencies on the pain from venous and arterial blood sampling: A clinical trial study.

The pain of the blood sampling process is an unpleasant and common experience in the treatment process. Stimulation the thalamus structure and corticothalamic pathways with at specific frequencies could play a role in modulating pain perception. The aim of this study was to investigate the use low a...

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Publicado en:Advances in Integrative Medicine Vol. 12; no. 4
Autores principales: Mohammadi, Saeed, Ezzati, Ebrahim, Mahooti, Rooghaye, Kavyannejad, Fatemeh, Paran, Mohammad Sadegh, Kavyannejad, Rasoul
Formato: research randomized controlled trial Journal Article
Publicado: Elsevier B.V. Dec2025
Acceso en línea:Ver este registro en EBSCOhost
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      dt: Dec2025
      vid: 12
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      pub: Elsevier B.V.
      place: New York, New York
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        189668007
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        10.1016/j.aimed.2025.100480
        189668007
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        atl: Investigating the effects of applying low acoustic frequencies on the pain from venous and arterial blood sampling: A clinical trial study.
      aug:
        au:
          Mohammadi, Saeed
          Ezzati, Ebrahim
          Mahooti, Rooghaye
          Kavyannejad, Fatemeh
          Paran, Mohammad Sadegh
          Kavyannejad, Rasoul
        affil: Department of Anesthesiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
      sug:
        subj:
          Acoustics
          Blood Specimen Collection
          Pain Management
          Hematologic Tests
          Human
          Randomized Controlled Trials
          Random Assignment
          Pretest-Posttest Design
          Comparative Studies
          Pain Measurement
          Heart Rate Variability
          Data Analysis Software
          Invasive Procedures
          Central Nervous System
      ab: The pain of the blood sampling process is an unpleasant and common experience in the treatment process. Stimulation the thalamus structure and corticothalamic pathways with at specific frequencies could play a role in modulating pain perception. The aim of this study was to investigate the use low acoustic frequencies in reducing pain during arterial and venous blood sampling. In a triple-blinded clinical trial study, 300 patients in each process were randomly divided into control and intervention groups. Patients in the intervention groups received sound frequencies of 10–200 Hz with an intensity of 50 dB during the procedures. Pain intensity, heart rate changes, number of attempts for successful sampling, and time required for each procedure were measured. Data were analyzed using Prism 10 software. Pain levels were significantly lower in the intervention groups with increasing sound frequencies in both procedures (P < 0.05). The duration of blood sampling procedures was significantly shorter with increasing sound frequency (P < 0.05), but no difference was observed in the frequency of sampling attempts (P > 0.05). By increasing the sound frequency, the intensity of tachycardia significantly decreased following the blood sampling process (P < 0.05), especially at higher frequencies. Applying low sound frequencies effectively could reduce acute pain and its consequences resulting from an invasive process. Sound frequencies appear to play a role in modulating pain pathways in the central nervous system. The study findings suggest that sound frequency ranges as a non-pharmacological analgesia intervention can be used to reduce pain and discomfort following a variety of blood sampling procedures, which performed by nurses.
      pubtype: Academic Journal
      doctype:
        research
        randomized controlled trial
        Journal Article
      ougenre: Article
    language: English
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