| Sumario: | Background: Zambia's Copperbelt Province maintains HIV prevalence of 11.9% among adults. PMC-Zambia conducted formative research in five districts (Ndola, Kitwe, Chingola, Kalulushi, Mpongwe) to inform a Radio Talk Show (RTS) addressing HIV prevention and pre-exposure prophylaxis (PrEP) uptake. Methods: We employed focus group discussions (FGDs) and key informant interviews (KIIs) across the districts. Semi-structured guides explored HIV perceptions, stigma, and PrEP awareness. Thematic and narrative analyses identified patterns and stakeholder perspectives. Results: Significant perception gaps emerged between healthcare workers reporting decreased stigma and community members describing persistent discrimination. PrEP awareness remained critically low with widespread misconceptions confusing prevention with lifelong treatment. Youth particularly feared partner suspicion and peer judgment, while older adults cited religious influences and relationship concerns as barriers. Conclusions: Findings reveal urgent need for targeted health communication bridging provider-community perception gaps, addressing misconceptions through expert dialogue, and leveraging interactive formats to reduce stigma while promoting informed HIV prevention decision-making.
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