Conclusions Are Not Supported by the Published Statistical Analysis. Comment on López-Toledo et al. Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial. Nutrients 2025, 17 , 709...Lopez-Toledo S, Pineda De la Cruz MC, Gutirrrez-Hurtado IA et al.
The article focuses on a randomized clinical trial by López-Toledo et al. that examined the effects of flaxseed powder on biochemical markers in adults with uncontrolled Type 2 diabetes. The study suggested that consuming 16 g of flaxseed daily for three months may lower glucose, total cholesterol,...
| Publicado en: | Nutrients Vol. 18; no. 1; pp. 170 - 172 |
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| Autores principales: | , , , , , |
| Formato: | commentary letter Journal Article |
| Publicado: |
MDPI
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | The article focuses on a randomized clinical trial by López-Toledo et al. that examined the effects of flaxseed powder on biochemical markers in adults with uncontrolled Type 2 diabetes. The study suggested that consuming 16 g of flaxseed daily for three months may lower glucose, total cholesterol, and triglyceride levels. However, the authors highlight a methodological concern regarding the use of within-group comparisons to draw conclusions about between-group differences, which can lead to a DINS (Difference in Nominal Significance) error and inflate the type I error rate. They emphasize the need for more robust statistical methods, such as ANCOVA, to ensure accurate comparisons and reproducibility of results. |
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