Conclusions Are Not Supported by the Published Statistical Analysis. Comment on López-Toledo et al. Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial. Nutrients 2025, 17 , 709...Lopez-Toledo S, Pineda De la Cruz MC, Gutirrrez-Hurtado IA et al.
The article focuses on a randomized clinical trial by López-Toledo et al. that examined the effects of flaxseed powder on biochemical markers in adults with uncontrolled Type 2 diabetes. The study suggested that consuming 16 g of flaxseed daily for three months may lower glucose, total cholesterol,...
| Publicado en: | Nutrients Vol. 18; no. 1; pp. 170 - 172 |
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| Autores principales: | , , , , , |
| Formato: | commentary letter Journal Article |
| Publicado: |
MDPI
Jan2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=190788167&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 190788167 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 20726643 B0TT jtl: Nutrients issn: 20726643 maglogo: N pubinfo: dt: Jan2026 vid: 18 iid: 1 pid: 97109 pub: MDPI artinfo: ui: 190788167 190788167 190788167 10.3390/nu18010170 190788167 ppf: 170 ppct: 2 formats: tig: atl: Conclusions Are Not Supported by the Published Statistical Analysis. Comment on López-Toledo et al. Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial. Nutrients 2025, 17 , 709...Lopez-Toledo S, Pineda De la Cruz MC, Gutirrrez-Hurtado IA et al. aug: au: Spitz, Robert W. Thapa, Deependra K. Mokalla, Thirupathi Reddy Najam, Wasiuddin Brown, Andrew W. Allison, David B. affil: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA sug: subj: Flaxseed Administration and Dosage Blood Glucose Metabolism Lipids Metabolism Mexicans Diabetes Mellitus, Type 2 Diet Therapy Glycemic Control Diabetic Patients Metformin Therapeutic Use Diabetes Mellitus, Type 2 Drug Therapy Cholesterol Blood Triglycerides Blood ab: The article focuses on a randomized clinical trial by López-Toledo et al. that examined the effects of flaxseed powder on biochemical markers in adults with uncontrolled Type 2 diabetes. The study suggested that consuming 16 g of flaxseed daily for three months may lower glucose, total cholesterol, and triglyceride levels. However, the authors highlight a methodological concern regarding the use of within-group comparisons to draw conclusions about between-group differences, which can lead to a DINS (Difference in Nominal Significance) error and inflate the type I error rate. They emphasize the need for more robust statistical methods, such as ANCOVA, to ensure accurate comparisons and reproducibility of results. pubtype: Academic Journal doctype: commentary letter Journal Article ougenre: Unknown language: English refInfo: holdings: @attributes: islocal: N |
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