The ORB2 RNA-binding protein negatively regulates its target transcripts during the Drosophila maternal-to-zygotic transition via its functionally conserved Zinc-binding "ZZ" domain.

Posttranscriptional regulation is particularly prominent during the maternal-to-zygotic transition (MZT), a developmental phase during which a large proportion of maternally provided mRNAs is repressed and cleared from metazoan embryos. RNA-binding proteins (RBPs) are key components of the posttrans...

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Bibliographic Details

Published in:	Genetics Vol. 232; no. 2; pp. 1 - 23
Main Authors:	Low, Timothy C H, Luo, Hua, Weerasooriya, Chalini, Wang, Zhuyi, Lin, Sichun, Karaiskakis, Angelo, Angers, Stephane, Smibert, Craig A, Lipshitz, Howard D
Format:	research tables/charts Journal Article
Published:	Oxford University Press / USA Feb2026
Online Access:	View this record in EBSCOhost