Depleting retinoic acid synthesis in the nucleus accumbens shell produces a protective phenotype for emotional reactivity and drug-taking in rats.
Rationale: In previous work, a convergent transcriptomic approach strongly suggested a role for retinoic acid (RA) in controlling the emotion- and reward-related functions of the nucleus accumbens shell (NAcSh). Objective: Here, we causally assess the role of NAcSh RA in controlling anxiety-, emotio...
| Published in: | Psychopharmacology Vol. 243; no. 1; pp. 59 - 75 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Published: |
Springer Nature
Jan2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191451163&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191451163 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 00333158 EJD jtl: Psychopharmacology issn: 00333158 maglogo: N pubinfo: dt: Jan2026 vid: 243 iid: 1 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 191451163 186331493 10.1007/s00213-025-06838-3 191451163 ppf: 59 ppct: 16 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Depleting retinoic acid synthesis in the nucleus accumbens shell produces a protective phenotype for emotional reactivity and drug-taking in rats. aug: au: Mármol Contreras, Yorkiris Dvorak, Nolan M. Tapia, Cynthia M. Zaman, Roxana Annareddy, Jyothika Balikosa, Yves Gupta, Nikita S. Rader, Alex P. Vasquez, Tileena E. S. Koshy, Shyny Li, Dingge Balaji, Varun K. Laezza, Fernanda Green, Thomas A. affil: https://ror.org/016tfm930 Department of Pharmacology and Toxicology, The University of Texas Medical Branch, 301 University Dr., Medical Research Bldg 7.102c, 77555, Galveston, TX, USA sug: ab: Rationale: In previous work, a convergent transcriptomic approach strongly suggested a role for retinoic acid (RA) in controlling the emotion- and reward-related functions of the nucleus accumbens shell (NAcSh). Objective: Here, we causally assess the role of NAcSh RA in controlling anxiety-, emotion-, and reward-related behavior in rats and explore cellular mechanisms that may underlie this phenotype. Methods: Rats underwent bilateral knockdown of the retinoic acid synthesis enzyme Aldh1a1 in the NAcSh. Anxiety-related behavior was assessed using open-field exploration, elevated plus maze, and sucrose neophobia tests. Emotion-related behavior was assessed via sucrose preference, post-isolation social contact, and forced swim tests. Animals were subsequently allowed to self-administer fentanyl to assess reward- and frustration-related behavior. In parallel, electrophysiological testing of medium spiny neurons (MSNs) in the NAcSh was used to explore the role of RA in NAcSh cellular function. Results: We observed an anxiety-vulnerable, depression-resilient phenotype in knockdown animals compared to controls. During operant tasks, knockdown animals took fewer fentanyl infusions during FR5 maintenance and showed decreased demand intensity in behavioral economics sessions. Finally, electrophysiological assessment of NAcSh MSNs revealed attenuated excitability following Aldh1a1 knockdown. Altogether, our findings reveal a key role for NAcSh RA signaling in determining emotional resilience and drug-taking, likely via decreased MSN excitability. Conclusions: Our results posit the RA synthesis enzyme Aldh1a1 as a promising therapeutic target for depression-, frustration-, and addiction-associated disorders. This is the first report linking RA to frustrative nonreward, the NAcSh to operant frustration, and RA to fentanyl drug-taking behavior. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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