| Sumario: | Due to the burden of diseases and adverse reactions to treatment, people with hematologic malignancies usually experience frailty. This study determined the risk factors associated with frailty in people with hematologic malignancies. A thorough examination of the literature was conducted across nine databases following the PRISMA guidelines, including PubMed, Web of Science Core Collection, Embase, CINAHL, CNKI, Wanfang Data, CBM, VIP Database, and SinoMed, covering the period from 2001 to July 26, 2024. The Newcastle-Ottawa Scale was used to assess the quality of the included studies, in conjunction with evaluation tools from the Agency for Healthcare Research and Quality. The analysis included 23 studies, encompassing 13,849 participants. A high prevalence of frailty was observed in this study, affecting 27.1% of the participants involved. Several risk factors for frailty were identified, including demographic traits (gender, age), clinical features (hand grip strength, physical activity, comorbidities, advanced disease stages, neurological symptoms), biochemical markers (albumin levels, interleukin-6), and mental state (anaemia, depressive symptoms). Our analysis suggests that frailty is common among people with hematologic malignancies. Nurses should pay attention to individuals who exhibit the above-mentioned influencing factors in clinical practice, prevent the occurrence and progression of frailty, and engage in multidisciplinary collaboration and multi-targeted interventions to better manage individuals with frailty.
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