Diterpenoids from the soft coral Pachyclavularia violacea and their anti-inflammatory activities.
The detailed chemical investigation of the South China Sea soft coral Pachyclavularia violacea, led to the isolation and characterization of a new casbane-type diterpenoid, 7,8-epoxy-casbene (1), along with seven known compounds (2–8). Their structures were determined by extensive spectroscopic anal...
| Publicado en: | Journal of Asian Natural Products Research Vol. 28; no. 3; pp. 506 - 515 |
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| Autores principales: | , , , , , , , |
| Formato: | pictorial tables/charts Journal Article |
| Publicado: |
Taylor & Francis Ltd
Mar2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=191985593&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 191985593 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 10286020 J40 jtl: Journal of Asian Natural Products Research issn: 10286020 maglogo: Y pubinfo: dt: Mar2026 vid: 28 iid: 3 pid: 377 pub: Taylor & Francis Ltd place: Philadelphia, Pennsylvania artinfo: ui: 191985593 185706333 191985593 191985593 10.1080/10286020.2025.2511896 191985593 ppf: 506 ppct: 9 formats: tig: atl: Diterpenoids from the soft coral Pachyclavularia violacea and their anti-inflammatory activities. aug: au: Du, Chen-Lu Zhao, Xue-Yao Xiao, Xiao Zhang, Chuan Guo, Yue-Wei Chen, Liang Wu, Yan-Wei Li, Song-Wei affil: School of Medicine, Shanghai University, Shanghai, 200444, China sug: subj: Hydrocarbons Analysis Invertebrates Analysis Antiinflammatory Agents Therapeutic Use Tumor Necrosis Factor Antagonists and Inhibitors Biological Products Pharmacodynamics Molecular Structure Funding Source China Experimental Studies Academic Medical Centers Magnetic Resonance Spectroscopy Chromatography Methods Cytotoxicity Tests, Immunologic Descriptive Statistics Comparative Studies Data Analysis Software Nuclear Physics Biological Assay Lipopolysaccharides Tumor Necrosis Factor ab: The detailed chemical investigation of the South China Sea soft coral Pachyclavularia violacea, led to the isolation and characterization of a new casbane-type diterpenoid, 7,8-epoxy-casbene (1), along with seven known compounds (2–8). Their structures were determined by extensive spectroscopic analysis, quantum mechanical nuclear magnetic resonance (QM-NMR) method, time-dependent density functional theory electronic circular dichroism (TDDFT-ECD) calculation, and comparison with the spectral data previously reported in the literature. In in vitro bioassays, the anti-inflammatory activities of the isolated compounds were evaluated in the lipopolysaccharide (LPS)-induced RAW 264.7 cells, and compounds 6–8 displayed interesting inhibitory effects on LPS-induced tumor necrosis factor (TNF)-α protein release with half-maximal inhibitory concentration (IC50) values of 201.1, 231.7, and 66.21 µM, respectively. pubtype: Academic Journal doctype: pictorial tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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