Analysis of the association between Healthy Eating Index (HEI)-2020 and diabetic kidney disease in type 2 diabetes patients: Based on the NHANES database.
Background: A rise in the Healthy Eating Index (HEI) 2020 is associated with a reduced risk of chronic kidney disease. However, it remains unclear whether HEI-2020 exhibits a similar positive effect in diabetic patients. Objectives: This work aimed to investigate the relationship between HEI-2020 an...
| Published in: | Nefrología Vol. 46; no. 3; pp. 1 - 10 |
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| Main Authors: | , , , , |
| Format: | Article |
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Revista Nefrologia
Mar2026
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| Online Access: | View this record in EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=lth&AN=192061895&site=ehost-live header: @attributes: shortDbName: lth uiTerm: 192061895 longDbName: MedicLatina uiTag: AN controlInfo: bkinfo: jinfo: jid: 02116995 50C3 jtl: Nefrología issn: 02116995 maglogo: N pubinfo: dt: Mar2026 vid: 46 iid: 3 pid: 39358 pub: Revista Nefrologia artinfo: ui: 192061895 10.1016/j.nefro.2025.501452 ppf: 1 ppct: 9 formats: fmt: @attributes: type: P size: 1.5MB tig: atl: Analysis of the association between Healthy Eating Index (HEI)-2020 and diabetic kidney disease in type 2 diabetes patients: Based on the NHANES database. aug: au: Dong, Chunping Li, Hui Li, Jing Qiao, Yuan Gao, Shan affil: Department of Endocrinology, Shaanxi Provincial People's Hospital, Xi'an City 710068, Shaanxi Province, China su: Type 2 diabetes Diabetic nephropathies Diet therapy Diet in disease Logistic regression analysis Chronic kidney failure National Health & Nutrition Examination Survey Nutritive value of feeds sug: subj: Type 2 diabetes Diabetic nephropathies Diet therapy Diet in disease Logistic regression analysis Chronic kidney failure National Health & Nutrition Examination Survey Nutritive value of feeds keyword: Diabetic kidney disease HEI-2020 National Health and Nutrition Examination Survey Diabetes tipo 2 Enfermedad renal diabética Encuesta Nacional de Examinación de Salud y Nutrición ab: Background: A rise in the Healthy Eating Index (HEI) 2020 is associated with a reduced risk of chronic kidney disease. However, it remains unclear whether HEI-2020 exhibits a similar positive effect in diabetic patients. Objectives: This work aimed to investigate the relationship between HEI-2020 and the prevalence of diabetic kidney disease (DKD) in type 2 diabetes (T2D) patients. Methods: A cross-sectional analysis was based on the National Health and Nutrition Survey database from 2007 to 2018. A weighted logistic regression model, restricted cubic splines, and subgroup analysis were undertaken to assess the relationship between HEI-2020 and the prevalence of DKD in T2D patients. A weighted logistic regression model and a weighted quantile sum (WQS) regression model were employed. The independent impact of HEI-2020-related components on the prevalence of DKD among T2D patients was analyzed. In addition, sensitivity analysis was conducted. Results: A total of 4255 participants with T2D were enrolled, with a DKD prevalence rate of 34.7%. The logistics regression analysis demonstrated a significant inverse relation between the HEI-2020 score and the prevalence of DKD in fully adjusted models (OR = 0.982, 95% CI: 0.973-0.992, P < 0.001). No nonlinear relationship was detected (P-non-linear = 0.970). No subgroup with significant interaction was identified. The WQS regression indicated that in fully adjusted models, the WQS index for HEI-2020 was significantly negatively correlated with the prevalence of DKD among T2D patients (OR = 0.765, 95% CI: 0.621-0.943, P = 0.012), with dairy products, total protein foods, and total vegetables as the most influential components. In addition, HEI-2020 was significantly negatively correlated with DKD in previously diagnosed T2D patients (OR = 0.979, 95% CI: 0.967-0.990, P < 0.001), while no significant association was observed in newly diagnosed patients. The sensitivity analysis yielded similar results, indicating that our results were robust. Conclusion: This research revealed a relationship between an increase in the HEI-2020 score and a lower prevalence of DKD among T2D patients, emphasizing the importance of the intake of dairy products, total protein foods, and total vegetables. This finding provides new scientific grounds for dietary management in T2D patients. Antecedentes: Un aumento en el Índice de Alimentación Saludable (HEI) 2020 se asocia con una reducción del riesgo de enfermedad renal crónica. Sin embargo, aún no está claro si el HEI-2020 tiene un efecto positivo similar en los pacientes diabéticos. Objetivos: El objetivo de este trabajo fue investigar la relación entre el HEI-2020 y la prevalencia de la enfermedad renal diabética (ERD) en pacientes con diabetes tipo 2 (DT2). Métodos: Se realizó un análisis transversal basado en la base de datos de la Encuesta Nacional de Salud y Nutrición (NHANES) de 2007 a 2018. Se emplearon un modelo de regresión logística ponderada, splines cúbicos restringidos y un análisis de subgrupos para evaluar la relación entre el HEI-2020 y la prevalencia de ERD en pacientes con DT2. Se utilizaron un modelo de regresión logística ponderada y un modelo de regresión ponderada de suma de cuantil (WQS). Se analizóel impacto independiente de los componentes relacionados con el HEI-2020 sobre la prevalencia de ERD en los pacientes con DT2. Además, se realizó un análisis de sensibilidad. Resultados: Se inscribieron un total de 4,255 participantes con DT2, con una tasa de prevalencia de ERD del 34.7%. El análisis de regresión logística demostróuna relación inversa significativa entre el puntaje del HEI-2020 y la prevalencia de ERD en los modelos completamente ajustados (OR = 0.982, IC del 95%: 0.973-0.992, P<0.001). No se detectóuna relación no lineal (P-no lineal = 0.970). No se identificóningún subgrupo con interacción significativa. La regresión WQS indicó que, en los modelos completamente ajustados, el índice WQS para el HEI-2020 se correlacionósignificativamente de manera negativa con la prevalencia de ERD en los pacientes con DT2 (OR = 0.765, IC del 95%: 0.621-0.943, P =0.012), siendo los productos lácteos, los alimentos con proteínas totales y los vegetales totales los componentes más influyentes. Además, el HEI-2020 se correlacionó significativamente de manera negativa con la ERD en los pacientes con DT2 previamente diagnosticados (OR=0.979, IC del 95%: 0.967-0.990, P<0.001), mientras que no se observóuna asociación significativa en los pacientes recién diagnosticados. El análisis de sensibilidad arrojóresultados similares, lo que indica que nuestros resultados son robustos. Conclusión: Esta investigación revelóuna relación entre el aumento en el puntaje del HEI-2020 y una menor prevalencia de ERD entre los pacientes con DT2, destacando la importancia de la ingesta de productos lácteos, alimentos con proteínas totales y vegetales totales. Este hallazgo proporciona una base científica nueva para la gestión dietética en pacientes con DT2. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y custom: Copyright of Nefrología is the property of Revista Nefrologia and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. item: Nefrología holder: Revista Nefrologia dt: @attributes: year: 2026 holdings: @attributes: islocal: N |
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