| Sumario: | Objectives: to describe cutaneous reactions caused by injected immunomodulators used for the treatment of multiple sclerosis (MS) and associated factors. Methods: a descriptive and analytical cross-sectional study was conducted with a nonprobability sample of MS patients undergoing treatment at a hospital's neuroimmunology center. The data were collected using structured interviews consisting of two instruments. Results: the sample consisted of 116 MS patients with an average age of 39.8 years, who were predominantly female (72.4%) and white (98.3%). The most prevalent type of MS was relapsing-remitting MS (70.0%). A total of 101 (87.0%) participants developed one or more cutaneous reactions at the injection site. The most frequent reactions were hyperemia (n = 86; 74%), sclerosis (n = 68; 59%), ecchymosis (n = 59; 51%), oedema (n = 53; 46%) and warmth (n = 50; 43%). Reactions were mostly mild and moderate intensity. The factors associated with reactions were depression (p = 0.01) and Body Mass Index considered to be obese (p = 0.04). Conclusions: a significant proportion of patients developed cutaneous reactions at the immunomodulator injection site, and the presence of reactions was associated with depression and obesity.
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