| Sumario: | Objective To examine the effects of a Physiotherapy-led, Person-Centred Integrated Care (PTICOPE) programme on intrinsic capacity (IC) (locomotion, vitality, psychological, cognitive, vision, hearing), and quality of life (QoL) among community-dwelling older adults. Methods Seventy-one older adults were randomised to PTICOPE (n = 35) or control health education (n = 36) for 12 weeks. PTICOPE included centre-based physiotherapy and home-based multidomain activities targeting all IC domains. IC was assessed using the Short Physical Performance Battery, Mini-Mental State Examination, Mini Nutritional Assessment–Short Form, Geriatric Depression Scale-15, Snellen acuity, and whispered-voice test at baseline and Weeks 4, 8, and 12. QoL was measured using the World Health Organization Quality of Life–Brief Version at baseline and Week 12. Primary analyses used intention-to-treat linear mixed-effects models adjusting for baseline values and education level. Per-protocol analyses included participants attending ≥10 sessions. Results PTICOPE improved locomotion (0.87; P = .030; ηp = 0.13), with smaller significant gains in vitality (0.67; P = .014; ηp = 0.09) and cognition (1.09; P = .035; ηp = 0.01). Changes in the psychological, visual, and auditory domains were not clinically meaningful. QoL improved across all domains: physical health (+6.2), psychological (+4.9), social relationships (+4.0), and environment (+4.1), all P <.001 with medium-to-large effect sizes. Sensitivity analyses confirmed similar patterns. Conclusions PTICOPE enhanced key IC domains, locomotion, vitality, and cognition, and produced meaningful improvements in QoL. These findings support physiotherapy-led, person-centred care as an effective community strategy for healthy ageing. Trials Registration Thai Clinical Trials (Number: TCTR20241029007).
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