Effects of a 24-week resistance exercise program on Alzheimer's disease brain signatures in cognitively unimpaired older adults: a secondary analysis of the AGUEDA randomized controlled trial.
Background Brain imaging markers may help detect early cognitive decline and Alzheimer's disease (AD). Although exercise-related effects on AD-specific brain signatures remain unclear. Objective To examine the effects of a 24-week resistance exercise (RE) program on AD brain signatures in cognitivel...
| Publicado en: | Age & Ageing Vol. 55; no. 4; pp. 1 - 16 |
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| Autores principales: | , , , , , , , |
| Formato: | Artículo |
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Oxford University Press / USA
Apr2026
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=193500082&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 193500082 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 00020729 AGA jtl: Age & Ageing issn: 00020729 maglogo: N pubinfo: dt: Apr2026 vid: 55 iid: 4 pid: 622 pub: Oxford University Press / USA artinfo: ui: 193500082 10.1093/ageing/afag086 ppf: 1 ppct: 15 formats: tig: atl: Effects of a 24-week resistance exercise program on Alzheimer's disease brain signatures in cognitively unimpaired older adults: a secondary analysis of the AGUEDA randomized controlled trial. aug: au: Sanchez-Martinez, Javier Solis-Urra, Patricio Fernandez-Gamez, Beatriz Fernández-Ortega, Javier Sánchez-Aranda, Lucía Erickson, Kirk I Ortega, Francisco B Esteban-Cornejo, Irene affil: Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, SpainNeuroscience Institute Orlando, AdventHealth Research Institute, Orlando, FL, USAFaculty of Education and Social Sciences, Andrés Bello University, Viña del Mar, Valparaíso, Chile Neuroscience Institute Orlando, AdventHealth Research Institute, Orlando, FL, USADepartment of Psychology, University of Pittsburgh, Pittsburgh, PA, USA Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, SpainCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, SpainInstituto de Investigación Biosanitaria (ibs.GRANADA), Granada, Spain su: Spain Evaluation of human services programs Episodic memory Executive function Aging Psychological tests Exercise physiology Rehabilitation of Alzheimer's patients Alzheimer's disease Secondary analysis Independent living Research funding Cognition disorders in old age Brain Cognitive processing speed Magnetic resonance imaging Descriptive statistics Resistance training Neuroradiology Digital image processing Confidence intervals Factor analysis Data analysis software sug: subj: Evaluation of human services programs Episodic memory Executive function Aging Psychological tests Spain Diagnostic Imaging Centers Exercise physiology Rehabilitation of Alzheimer's patients Alzheimer's disease Secondary analysis Independent living Research funding Cognition disorders in old age Brain Cognitive processing speed Magnetic resonance imaging Descriptive statistics Resistance training Neuroradiology Digital image processing Confidence intervals Factor analysis Data analysis software keyword: aging alzheimer's disease brain brain cortical thickness cognition copyrightHolder:British Geriatrics Society copyrightYear:2026 diffusion magnetic resonance imaging exercise gray matter https://dx.doi.org/10.1093/ageing/afag086 inLanguage:en older adult older people publisher:Oxford University Press resistive exercise sameAs:https://pubmed.ncbi.nlm.nih.gov/41967036/ secondary data analysis aging alzheimer's disease brain brain cortical thickness cognition copyrightHolder:British Geriatrics Society copyrightYear:2026 diffusion magnetic resonance imaging exercise gray matter https://dx.doi.org/10.1093/ageing/afag086 inLanguage:en older adult older people publisher:Oxford University Press resistive exercise sameAs:https://pubmed.ncbi.nlm.nih.gov/41967036/ secondary data analysis ab: Background Brain imaging markers may help detect early cognitive decline and Alzheimer's disease (AD). Although exercise-related effects on AD-specific brain signatures remain unclear. Objective To examine the effects of a 24-week resistance exercise (RE) program on AD brain signatures in cognitively unimpaired older adults, to explore potential moderators and to assess associations with cognition, including mediation effects. Methods This secondary analysis of a single-site, two-arm, single-blinded randomized controlled trial included 90 participants (72 ± 4 years; 58% female) randomly assigned by a blind external researcher to an RE group (3 sessions/week, 60 min/session, n = 46) or a wait-list control group (CG, n = 44). T1- and diffusion-weighted MRI were acquired at baseline and post-intervention. Primary outcomes were thickness/volume and grey matter mean diffusivity (GMMD) signatures, derived from cortical and hippocampal regions. Moderators included age, sex, education, multimorbidity, apolipoprotein E ϵ4 status, amyloid beta (Aβ) status and baseline AD brain signatures. Secondary outcomes included cognitive function. Outcome measures and analyses were conducted by staff blinded to intervention assignment. Results Compared with the CG, the RE group showed a reduction in the thickness/volume signature (−0.23 standardized mean difference [SMD]; 95% CI, −0.43 to −0.02), but no effect on the GMMD signature (0.08 SMD; 95% CI, −0.13 to 0.29). Aβ-status moderated the effect, as Aβ-positive participants in the RE group showed a larger reduction in the thickness/volume signature than those in the CG (−0.64 SMD; 95% CI, −1.09 to −0.18), whereas no effect was observed in Aβ-negative participants. Thickness/volume and GMMD reductions were associated with improvements in executive function and attentional/inhibitory control, respectively. Changes in AD signatures did not mediate cognitive outcomes. Conclusion Our findings suggest that reductions in the macrostructural AD signature following a 24-week RE program may reflect adaptive, rather than detrimental, brain changes, particularly in Aβ-positive older adults, as these changes were associated with improved executive function. Trial registration Registered on Clinicaltrials.gov (Identifier: NCT05186090). pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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