Sodium Selenite Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension by Upregulating GPX3 and Ameliorating Vascular Remodeling.
Selenium deficiency is implicated in pulmonary arterial hypertension (PAH). This study investigated the effects of sodium selenite (SSE) on PAH and its underlying mechanisms. In a monocrotaline-induced PAH rat model, SSE treatment significantly improved right ventricular systolic pressure (RVSP), me...
| Publicado en: | Physiological Research Vol. 75; no. 2; pp. 325 - 336 |
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| Autores principales: | , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
Institute of Physiology, Academy of Sciences of the Czech Republic
Apr2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=193846125&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 193846125 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 08628408 1CVW jtl: Physiological Research issn: 08628408 maglogo: N pubinfo: dt: Apr2026 vid: 75 iid: 2 pid: 24634 pub: Institute of Physiology, Academy of Sciences of the Czech Republic artinfo: ui: 193846125 10.33549/physiolres.935734 193846125 ppf: 325 ppct: 11 formats: fmt: @attributes: type: P tig: atl: Sodium Selenite Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension by Upregulating GPX3 and Ameliorating Vascular Remodeling. aug: au: LIU, Zihua LIU, Xue MPRAH, Richard SUN, Hong ADU-AMANKWAAH, Joseph PAN, Xiuhua CHENG, Shouquan XIE, Bing WANG, Cheng QIAO, Weili affil: Department of Physiology, Xuzhou Medical University, Xuzhou, Jiangsu, China. sug: ab: Selenium deficiency is implicated in pulmonary arterial hypertension (PAH). This study investigated the effects of sodium selenite (SSE) on PAH and its underlying mechanisms. In a monocrotaline-induced PAH rat model, SSE treatment significantly improved right ventricular systolic pressure (RVSP), mean pulmonary arterial pressure (mPAP), and vascular remodeling. It reduced collagen deposition and partially restored the expression of Collagen 1 and SM22α. SSE upregulated glutathione peroxidase 3 (GPX3) expression and attenuated oxidative stress, as evidenced by enhanced SOD activity and decreased MDA levels. In vitro, SSE inhibited H₂O₂ and angiotensin II-induced proliferation, oxidative stress, and phenotypic switching in pulmonary artery smooth muscle cells (PASMCs), while upregulating GPX3 at both mRNA and protein levels. These findings demonstrate that SSE alleviates PAH by enhancing GPX3-mediated antioxidant defense and suppressing vascular remodeling, supporting its potential as a therapeutic strategy for PAH. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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