| Sumario: | Simple Summary: Triple-negative breast cancer (TNBC) is a type of breast cancer that typically grows and spreads more quickly than other breast cancer subtypes. In recent years, new treatments have significantly improved outcomes for people with TNBC. As treatment options evolve, there is a need to ensure that care across Canada remains aligned with the best available evidence and delivered in a consistent manner. Research Excellence, Active Leadership Canadian Breast Cancer Alliance (REAL Alliance), in partnership with Breast Cancer Canada, developed national, expert-based recommendations to guide the management of TNBC. REAL Alliance is a pan-Canadian group of breast cancer specialists, and Breast Cancer Canada represents the patient voice. Using a review of current research and a structured consensus process involving experts in medical oncology, radiation oncology, surgical oncology, and pharmacy, the group developed 23 clinical recommendations for TNBC care. These include four general recommendations, 11 recommendations for early-stage TNBC, and eight recommendations for metastatic TNBC. These recommendations are intended to support oncology healthcare professionals in delivering evidence-based, consistent, and high-quality care for people living with TNBC across Canada. Triple-negative breast cancer (TNBC) has been associated with a poorer prognosis than other subtypes, due to its more aggressive behaviour. Since 2020, significant advances in locoregional and systemic therapy have improved outcomes for patients with TNBC, but the implementation of these treatments remains inconsistent across Canada. There is, therefore, a critical need for evidence-informed, consensus-driven guidance to support the integration of new therapies into practice. Research Excellence, Active Leadership Canadian Breast Cancer Alliance (REAL Alliance), a pan-Canadian group of breast cancer specialists and Breast Cancer Canada, a patient advocacy organization, convened to develop national clinical consensus recommendations for the management of breast cancer. Through a selective literature review and modified Delphi process of national experts in the fields of medical oncology, radiation oncology, surgical oncology and pharmacy, REAL Alliance developed national consensus recommendations for the management of TNBC. The result is a set of 23 recommendations: four overall general recommendations, 11 in early-stage TNBC, and eight in metastatic TNBC. These recommendations are intended for oncology healthcare professionals, and are intended to guide evidence-informed, consistent care across Canada.
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