Guidance for Canadian Breast Cancer Practice: National Consensus Recommendations for the Systemic Treatment of Patients with Triple Negative Breast Cancer in Both the Early and Metastatic Setting 2025.
Simple Summary: Triple-negative breast cancer (TNBC) is a type of breast cancer that typically grows and spreads more quickly than other breast cancer subtypes. In recent years, new treatments have significantly improved outcomes for people with TNBC. As treatment options evolve, there is a need to...
| Publicado en: | Current Oncology Vol. 33; no. 5; pp. 243 - 281 |
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| Autores principales: | , , , , , , , , , , , , , , , , , |
| Formato: | Journal Article |
| Publicado: |
MDPI
May2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=194129115&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 194129115 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 11980052 5EKK jtl: Current Oncology issn: 11980052 maglogo: N pubinfo: dt: May2026 vid: 33 iid: 5 pid: 97109 pub: MDPI artinfo: ui: 194129115 10.3390/curroncol33050243 194129115 ppf: 243 ppct: 38 formats: fmt: – @attributes: type: T – @attributes: type: P tig: atl: Guidance for Canadian Breast Cancer Practice: National Consensus Recommendations for the Systemic Treatment of Patients with Triple Negative Breast Cancer in Both the Early and Metastatic Setting 2025. aug: au: Simmons, Christine Khan, Omar F. Brezden-Masley, Christine Cescon, David W. Joy, Anil Abraham LeVasseur, Nathalie Jerzak, Katarzyna J. Gelmon, Karen A. Sehdev, Sandeep Chia, Stephen Webster, Marc Edwards, Scott Kumar, Aalok Cao, Jeffrey Q. Boileau, Jean-François Laing, Kara Bouganim, Nathaniel Manna, Mita affil: BC Cancer—Vancouver, University of British Columbia, Vancouver, BC V5Z 4E6, Canada sug: ab: Simple Summary: Triple-negative breast cancer (TNBC) is a type of breast cancer that typically grows and spreads more quickly than other breast cancer subtypes. In recent years, new treatments have significantly improved outcomes for people with TNBC. As treatment options evolve, there is a need to ensure that care across Canada remains aligned with the best available evidence and delivered in a consistent manner. Research Excellence, Active Leadership Canadian Breast Cancer Alliance (REAL Alliance), in partnership with Breast Cancer Canada, developed national, expert-based recommendations to guide the management of TNBC. REAL Alliance is a pan-Canadian group of breast cancer specialists, and Breast Cancer Canada represents the patient voice. Using a review of current research and a structured consensus process involving experts in medical oncology, radiation oncology, surgical oncology, and pharmacy, the group developed 23 clinical recommendations for TNBC care. These include four general recommendations, 11 recommendations for early-stage TNBC, and eight recommendations for metastatic TNBC. These recommendations are intended to support oncology healthcare professionals in delivering evidence-based, consistent, and high-quality care for people living with TNBC across Canada. Triple-negative breast cancer (TNBC) has been associated with a poorer prognosis than other subtypes, due to its more aggressive behaviour. Since 2020, significant advances in locoregional and systemic therapy have improved outcomes for patients with TNBC, but the implementation of these treatments remains inconsistent across Canada. There is, therefore, a critical need for evidence-informed, consensus-driven guidance to support the integration of new therapies into practice. Research Excellence, Active Leadership Canadian Breast Cancer Alliance (REAL Alliance), a pan-Canadian group of breast cancer specialists and Breast Cancer Canada, a patient advocacy organization, convened to develop national clinical consensus recommendations for the management of breast cancer. Through a selective literature review and modified Delphi process of national experts in the fields of medical oncology, radiation oncology, surgical oncology and pharmacy, REAL Alliance developed national consensus recommendations for the management of TNBC. The result is a set of 23 recommendations: four overall general recommendations, 11 in early-stage TNBC, and eight in metastatic TNBC. These recommendations are intended for oncology healthcare professionals, and are intended to guide evidence-informed, consistent care across Canada. pubtype: Academic Journal doctype: Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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