Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence–enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative.
Background: There is an urgent need to evaluate the efficacy of novel therapeutics that have been approved for use in adults with IgA nephropathy (IgAN) in pediatric patients with this primary glomerular disease. Methods: To explore the feasibility of deploying extrapolation to promote clinical tria...
| Publicado en: | Pediatric Nephrology Vol. 41; no. 8; pp. 2481 - 2488 |
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| Autores principales: | , , , , , , , , , , , , , , , , |
| Formato: | review tables/charts Journal Article |
| Publicado: |
Springer Nature
Aug2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195149875&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195149875 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 0931041X EF1 jtl: Pediatric Nephrology issn: 0931041X maglogo: N pubinfo: dt: Aug2026 vid: 41 iid: 8 pid: 237 pub: Springer Nature place: New York, New York artinfo: ui: 195149875 192142006 195149875 195149875 10.1007/s00467-026-07245-2 195149875 ppf: 2481 ppct: 7 formats: tig: atl: Promoting clinical trials in pediatric IgA nephropathy through extrapolation: an artificial intelligence–enhanced literature review of the disease in pediatrics sponsored by the Kidney Health Initiative. aug: au: Selewski, David T. Kerr, Eleanor M. Fajardo, Cecile Gillespie, Barbara S. Iyer, Sai Prasad N. Khalid, Myda Komers, Radko Nakanishi, Koichi Nelson, Raoul D. Oh, Jun Schneider, Bonnie Shah, Lokesh N. Webb, Nicholas J. Zhong, Xuhui Squillaci, Grace Lim, Mark D. Trachtman, Howard affil: https://ror.org/00xcryt71 Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA sug: subj: Clinical Trials Pediatric Care Glomerulonephritis Diagnosis Glomerulonephritis Drug Therapy Glomerulonephritis Prognosis Artificial Intelligence Utilization Severity of Illness Kidney Pathology Disease Progression Risk Factors Proteinuria Blood Creatinine Blood Risk Assessment ab: Background: There is an urgent need to evaluate the efficacy of novel therapeutics that have been approved for use in adults with IgA nephropathy (IgAN) in pediatric patients with this primary glomerular disease. Methods: To explore the feasibility of deploying extrapolation to promote clinical trials in pediatric patients with IgA nephropathy (IgAN), an artificial intelligence (AI)–enhanced review of the published literature through 2023 was conducted to characterize the epidemiology and natural history of IgA nephropathy, summarize the clinical trial experience, and identify potential biomarkers for use in patient care and clinical trials. Results: Using Distiller SR® software to identify relevant articles and Elicit®, an artificial intelligence tool to extract content, 83 articles were included in the review. The clinical trial reports (n = 9) and biomarker studies (n = 33) were limited in scope. The natural history and epidemiology articles (n = 41) suggested that the severity of kidney histopathology at the time of diagnosis indicated a higher risk of disease progression while proteinuria < 0.5–1 mg/mg creatinine was associated with a more favorable prognosis. Conclusions: In conjunction with the similar biological basis of the disease in pediatric and adult patients, these findings may enable the use of extrapolation in the design of clinical trials in pediatric patients with IgAN. A higher resolution version of the Graphical abstract is available as Supplementary information pubtype: Academic Journal doctype: review tables/charts Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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