| Sumario: | Background and Aim: Mucoadhesive drug delivery systems are a type of novel drug delivery system predominantly available in the form of polymeric films. These films extend the drug release time and create a high concentration gradient for drug penetration, leading to enhanced drug absorption. The aim of this study was to prepare and evaluate polymeric films containing eugenol for the improvement of mild to moderate oral cavity wounds and inflammation. Methods: In this experimental study, mucoadhesive films containing eugenol were prepared using the Solvent Casting method, employing ingredients such as HPMC (Hydroxy propyl methyl cellulose) powder as the filmforming polymer and glycerin as a plasticizer. The films were evaluated for their physical and pharmaceutical properties, including weight, thickness, disintegration time, drug release, and release profile. Results: The results indicated that formulations with higher eugenol concentrations, such as F5, exhibited higher absorption, suggesting stronger therapeutic effects. Cumulative release profiles showed that this formulation, with a faster release rate (95.5% in 60 minutes), is suitable for quicker treatments compared to other formulations. Conclusion: Parameters from the Korsmeyer-Peppas equation indicated that formulations with n values close to 1, utilizing both diffusion and swelling processes, exhibited faster drug release. Formulations with higher glycerin content, including F5, demonstrated a higher release rate, making them suitable for rapid treatments. Overall, these formulations can be designed for treatments with specific needs, such as rapid or controlled therapies.
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