تهیه و ارزیاب ي فیزیکوشی میایي فیل مهای مخاط چسب حاوی اوژنول)عصاره میخک (
Background and Aim: Mucoadhesive drug delivery systems are a type of novel drug delivery system predominantly available in the form of polymeric films. These films extend the drug release time and create a high concentration gradient for drug penetration, leading to enhanced drug absorption. The aim...
| Publicado en: | Journal of Military Medicine Vol. 28; no. 1; pp. 3139 - 3148 |
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| Autores principales: | , , , |
| Formato: | research tables/charts Journal Article |
| Publicado: |
Baqiyatallah University of Medical Sciences
May/Jun2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195305574&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195305574 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 17351537 B9ZL jtl: Journal of Military Medicine issn: 17351537 maglogo: N pubinfo: dt: May/Jun2026 vid: 28 iid: 1 pid: 63671 pub: Baqiyatallah University of Medical Sciences place: , <Blank> artinfo: ui: 195305574 195305574 195305574 10.30491/jmm.2026.1006949.1401 195305574 ppf: 3139 ppct: 9 formats: tig: atl: تهیه و ارزیاب ي فیزیکوشی میایي فیل مهای مخاط چسب حاوی اوژنول)عصاره میخک ( aug: au: علي صادقي سعید لطفي ابراهیم سلیمي صبور مریم ایمان affil: گروه فارماسیوتیکس، دانشکده داروسازی، دانشگاه علوم پزشکی بقیه الله)عج(، تهران، ایرا sug: subj: Mouth Mucosa Adhesives Analysis Polymers Analysis Drug Delivery Systems Evaluation Acids, Carbocyclic Administration and Dosage Phytochemicals Administration and Dosage Plant Oils Administration and Dosage Plant Extracts Administration and Dosage Plants, Medicinal Antiinflammatory Agents Administration and Dosage Stomatitis, Aphthous Drug Therapy Stomatitis Drug Therapy Chemistry, Pharmaceutical Chemistry, Analytical Administration, Buccal Experimental Studies Cellulose Powders Glycerin Plasticizers Comparative Studies Delayed-Action Preparations Plant Extracts Pharmacokinetics In Vitro Studies Spectrophotometry One-Way Analysis of Variance Descriptive Statistics Plant Extracts Pharmacodynamics Plant Oils Pharmacokinetics Plant Oils Pharmacodynamics ab: Background and Aim: Mucoadhesive drug delivery systems are a type of novel drug delivery system predominantly available in the form of polymeric films. These films extend the drug release time and create a high concentration gradient for drug penetration, leading to enhanced drug absorption. The aim of this study was to prepare and evaluate polymeric films containing eugenol for the improvement of mild to moderate oral cavity wounds and inflammation. Methods: In this experimental study, mucoadhesive films containing eugenol were prepared using the Solvent Casting method, employing ingredients such as HPMC (Hydroxy propyl methyl cellulose) powder as the filmforming polymer and glycerin as a plasticizer. The films were evaluated for their physical and pharmaceutical properties, including weight, thickness, disintegration time, drug release, and release profile. Results: The results indicated that formulations with higher eugenol concentrations, such as F5, exhibited higher absorption, suggesting stronger therapeutic effects. Cumulative release profiles showed that this formulation, with a faster release rate (95.5% in 60 minutes), is suitable for quicker treatments compared to other formulations. Conclusion: Parameters from the Korsmeyer-Peppas equation indicated that formulations with n values close to 1, utilizing both diffusion and swelling processes, exhibited faster drug release. Formulations with higher glycerin content, including F5, demonstrated a higher release rate, making them suitable for rapid treatments. Overall, these formulations can be designed for treatments with specific needs, such as rapid or controlled therapies. pubtype: Academic Journal doctype: research tables/charts Journal Article ougenre: Article language: Persian refInfo: holdings: @attributes: islocal: N |
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