Call to action – a novel strategy to improve clinical trial recruitment.
The article focuses on challenges and innovations in patient recruitment for molecularly targeted oncology clinical trials, using the Breast Cancer Trials (BCT) Olaparib + ImmunOtherapy (OLIO) trial as a case study. It highlights that strict molecular eligibility criteria, such as homologous recombi...
| Publicado en: | Internal Medicine Journal Vol. 56; no. 7; pp. 1268 - 1270 |
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| Autores principales: | , , , |
| Formato: | letter Journal Article |
| Publicado: |
Wiley-Blackwell
Jul2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ccm&AN=195683467&site=ehost-live header: @attributes: shortDbName: ccm uiTerm: 195683467 longDbName: CINAHL Complete uiTag: AN controlInfo: bkinfo: dissinfo: jinfo: jid: 14440903 HYC jtl: Internal Medicine Journal issn: 14440903 maglogo: Y pubinfo: dt: Jul2026 vid: 56 iid: 7 pid: 480 pub: Wiley-Blackwell place: Malden, Massachusetts artinfo: ui: 195683467 195175234 195683467 195683467 10.1111/imj.70492 195683467 ppf: 1268 ppct: 2 formats: tig: atl: Call to action – a novel strategy to improve clinical trial recruitment. aug: au: Zardawi, Sarah Zdenkowski, Nicholas Hay, Tracey Badger, Heath affil: Trials Department, Breast Cancer Trials, Newcastle New South Wales,, Australia sug: subj: Clinical Trials Research Subject Recruitment Strategic Planning Oncologic Care Eligibility Determination Cancer Screening Tumor Markers, Biological Breast Neoplasms Neoadjuvant Therapy Chemotherapy, Cancer Telehealth Rural Areas Oncologists Remote Patient Monitoring ab: The article focuses on challenges and innovations in patient recruitment for molecularly targeted oncology clinical trials, using the Breast Cancer Trials (BCT) Olaparib + ImmunOtherapy (OLIO) trial as a case study. It highlights that strict molecular eligibility criteria, such as homologous recombination deficiency (HRD) status, limit patient enrollment, prompting the removal of such criteria in OLIO due to low recruitment. To address these challenges, BCT developed a remote telehealth pre-screening process to facilitate molecular testing and patient identification across non-trial sites, aiming to broaden access and improve trial participation. Despite limited uptake among clinicians during the OLIO pilot, the approach shows potential for wider application, though barriers remain in data management and system compliance. The article calls for increased clinician engagement with telehealth pre-screening and further innovation to enhance recruitment efficiency and trial generalizability in oncology research. pubtype: Academic Journal doctype: letter Journal Article ougenre: Article language: English refInfo: holdings: @attributes: islocal: N |
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