Assessing the Clinical Relevance of BRCA1 RING Domain Variants of Uncertain Significance.

Simple Summary: Women who inherit harmful variants in the BRCA1 tumour suppressor gene have an elevated risk of developing multiple cancers, and may benefit from increased screening and preventative surgeries. Unfortunately, ~40% of BRCA1 variants have an unknown effect on cancer risk, leaving their...

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Bibliographic Details

Published in:	Current Oncology Vol. 33; no. 7; pp. 399 - 424
Main Authors:	Martin, Matthew D., Torretto, Gabriella C., Islam, Kaamraan, Archer, Nicole E., Feilotter, Harriet E., Davey, Scott K.
Format:	Journal Article
Published:	MDPI Jul2026
Online Access:	View this record in EBSCOhost