Autonomy, Trust, and Stewardship: Centering Participants in AI-Enabled Trial Matching.

The article focuses on the ethical considerations and practical implications of using artificial intelligence (AI) as a tool for clinical research recruitment, specifically in trial matching and recruitment processes. It distinguishes between participant-to-trial matching, where individuals or clini...

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Publicado en:American Journal of Bioethics Vol. 26; no. 8; pp. 49 - 53
Autores principales: Heidelberg, Melissa, Kultgen, Benjamin, Butler, Kelly K., Bott, Nicholas T.
Formato: commentary Journal Article
Publicado: Taylor & Francis Ltd Aug2026
Acceso en línea:Ver este registro en EBSCOhost
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        atl: Autonomy, Trust, and Stewardship: Centering Participants in AI-Enabled Trial Matching.
      aug:
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          Heidelberg, Melissa
          Kultgen, Benjamin
          Butler, Kelly K.
          Bott, Nicholas T.
        affil: Takeda Pharmaceuticals
      sug:
        subj:
          Research, Medical
          Clinical Trials
          Artificial Intelligence Utilization
          Research Subjects
          Patient Autonomy
          Trust
          Data Security
          Artificial Intelligence Ethical Issues
          Research Subject Recruitment
          Cost Savings
          Ecosystem
          Privacy and Confidentiality
          Digital Health
          Bioethics
      ab: The article focuses on the ethical considerations and practical implications of using artificial intelligence (AI) as a tool for clinical research recruitment, specifically in trial matching and recruitment processes. It distinguishes between participant-to-trial matching, where individuals or clinicians seek relevant trials using AI tools, and trial-to-participant matching, where researchers or sponsors identify eligible participants through AI-enabled data analysis. The discussion emphasizes situating AI trial matching within a broader ecosystem involving data stewardship, institutional coordination, participant autonomy, and public trust, highlighting the importance of transparency, meaningful consent, fairness, and oversight. The article also notes the growing role of AI in accelerating trial enrollment, reducing costs, and potentially improving inclusivity in clinical research, while underscoring the need for responsible deployment aligned with bioethical principles and regulatory compliance.
      pubtype: Academic Journal
      doctype:
        commentary
        Journal Article
      ougenre: Article
    language: English
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