Neuroticism mediates the link of resting-state brain activity and connectivity to subthreshold depression in older women.
Objectives The neurobiology of subthreshold depression, a prevalent and debilitating condition among older women, remains poorly understood. Neuroticism is a known depression risk factor, yet its role in linking brain function to depressive symptoms in this population is understudied. This study inv...
| Publicado en: | Journals of Gerontology Series B: Psychological Sciences & Social Sciences Vol. 81; no. 8; pp. 1 - 12 |
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| Autores principales: | , , |
| Formato: | Artículo |
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Oxford University Press / USA
Aug2026
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=ssf&AN=195931920&site=ehost-live header: @attributes: shortDbName: ssf uiTerm: 195931920 longDbName: Social Sciences Full Text (H.W. Wilson) uiTag: AN controlInfo: bkinfo: jinfo: jid: 10795014 JGB jtl: Journals of Gerontology Series B: Psychological Sciences & Social Sciences issn: 10795014 maglogo: N pubinfo: dt: Aug2026 vid: 81 iid: 8 pid: 622 pub: Oxford University Press / USA artinfo: ui: 195931920 10.1093/geronb/gbag101 ppf: 1 ppct: 11 formats: tig: atl: Neuroticism mediates the link of resting-state brain activity and connectivity to subthreshold depression in older women. aug: au: Wu, Dongmei Jiang, Jing Wang, Song affil: Department of Radiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nursing, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Department of Radiology, The Affiliated Hospital of Southwest Jiao Tong University, The Third People's Hospital of Chengdu, Chengdu, China Department of Radiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nursing, Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China su: China Cross-sectional method Mental health Psychology of women Case-control method Neuroses Mental depression Brain physiology Statistical power analysis Pearson correlation (Statistics) Functional connectivity Research funding Center for Epidemiologic Studies Depression Scale T-test (Statistics) Fisher exact test Prefrontal cortex Magnetic resonance imaging Time series analysis Chi-squared test Descriptive statistics Geriatric Depression Scale Comparative studies Factor analysis Neuroradiology Confidence intervals Data analysis software Nonparametric statistics sug: subj: Cross-sectional method Mental health Psychology of women Case-control method Neuroses Mental depression China Diagnostic Imaging Centers Offices of Mental Health Practitioners (except Physicians) Brain physiology Statistical power analysis Pearson correlation (Statistics) Functional connectivity Research funding Center for Epidemiologic Studies Depression Scale T-test (Statistics) Fisher exact test Prefrontal cortex Magnetic resonance imaging Time series analysis Chi-squared test Descriptive statistics Geriatric Depression Scale Comparative studies Factor analysis Neuroradiology Confidence intervals Data analysis software Nonparametric statistics keyword: aged Amplitude of low-frequency fluctuations copyrightHolder:The Gerontological Society of America copyrightYear:2026 depressive disorders Depressive symptoms functional magnetic resonance imaging https://dx.doi.org/10.1093/geronb/gbag101 inLanguage:en neuroticism publisher:Oxford University Press Resting-state fMRI sameAs:https://pubmed.ncbi.nlm.nih.gov/42261263/ aged Amplitude of low-frequency fluctuations copyrightHolder:The Gerontological Society of America copyrightYear:2026 depressive disorders Depressive symptoms functional magnetic resonance imaging https://dx.doi.org/10.1093/geronb/gbag101 inLanguage:en neuroticism publisher:Oxford University Press Resting-state fMRI sameAs:https://pubmed.ncbi.nlm.nih.gov/42261263/ ab: Objectives The neurobiology of subthreshold depression, a prevalent and debilitating condition among older women, remains poorly understood. Neuroticism is a known depression risk factor, yet its role in linking brain function to depressive symptoms in this population is understudied. This study investigated neurofunctional alterations in older women with subthreshold depression and tested whether neuroticism statistically explains the link between neural alterations and depressive symptoms. Methods 50 older women with subthreshold depression and 52 healthy older women controls underwent resting-state fMRI. Amplitude of low-frequency fluctuations (ALFF) and seed-based resting-state functional connectivity (RSFC) were analyzed. Depressive symptoms were assessed using the Geriatric Depression Scale and Center for Epidemiologic Studies Depression Scale, and personality traits with the Big Five Inventory-2. Mediation analyses examined the indirect effects of neuroticism. Results Compared to controls, older women with subthreshold depression showed higher depression and neuroticism scores and lower scores on other personality traits. Neuroimaging revealed greater ALFF in the left lateral orbitofrontal cortex (LOFC) and increased RSFC between the LOFC and medial OFC (MOFC) in the subthreshold depression group. These neural alterations positively correlated with depressive symptoms across all participants. Notably, only neuroticism correlated with both LOFC ALFF and LOFC–MOFC RSFC, and positively mediated the link between these neural markers and depressive symptoms. Discussion Older women with subthreshold depression exhibit OFC dysfunction, with neuroticism mediating the link to depressive symptoms. These findings elucidate a neuropsychological pathway linking intrinsic brain function to depressive symptomatology via personality vulnerability, offering potential targets for early identification and intervention in this at-risk population. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: N holdings: @attributes: islocal: N |
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