| Sumario: | Objectives: Health-related social influence refers to individual efforts to change another person's health beliefs and/or behavior. We sought to understand perspectives on social influence among adult siblings in families with an inherited cancer syndrome, Li-Fraumeni Syndrome (LFS). Design: An interprofessional team conducted 16 semi-structured interviews with sibling groups (n = 29, aged 18–66, 2–3 siblings per group) enrolled in the NCI's LFS Study. Main Outcome Measures: A semi-structured interview guide included questions targeting family closeness, information sharing, and perspectives on screening and cancer care. The research team collaboratively conducted thematic analysis on verbatim transcripts. Results: Participants reported attempts to influence their siblings' thoughts or behavior regarding LFS-related genetic testing and cancer screening, prevention, and treatment. Some participants expressed respect for sibling autonomy regarding risk management decisions. Others reported explicit attempts to change their siblings' perspective or behavior due to concern for their siblings' health. Conclusion: Findings suggest participants believed their influence meaningfully affected siblings' LFS risk management, indicating such influence comprises a social intervention pathway with potential to increase cascade testing and to support risk management. However, for some siblings, such efforts incurred risk of relational conflict. Future research might aim to help adult siblings balance social influence strategies with relational maintenance behaviors.
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