Computational Design of a Single Amino Acid Sequence that Can Switch between Two Distinct Protein Folds.
The functions of many proteins are mediated by specific conformational changes, and therefore the ability to design primary sequences capable of secondary and tertiary changes is an important step toward the creation of novel functional proteins. To this end, we have developed an algorithm that can...
| Publicado en: | Journal of the American Chemical Society Vol. 128; no. 4; pp. 1154 - 1162 |
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| Autores principales: | , |
| Formato: | Artículo |
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American Chemical Society
2/1/2006
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| Acceso en línea: | Ver este registro en EBSCOhost |