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Computational Design of a Single Amino Acid Sequence that Can Switch between Two Distinct Protein Folds.

The functions of many proteins are mediated by specific conformational changes, and therefore the ability to design primary sequences capable of secondary and tertiary changes is an important step toward the creation of novel functional proteins. To this end, we have developed an algorithm that can...

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Published in:Journal of the American Chemical Society Vol. 128; no. 4; pp. 1154 - 1162
Main Authors: Ambroggio, Xavier I., Kuhlman, Brian
Format: Article
Published: American Chemical Society 2/1/2006
Subjects:
Protein analysis
Amino acids
Protein folding
Biomolecules
Monte Carlo method
Computer software development
Online Access:View this record in EBSCOhost

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