On the Affinity Regulation of the Metal-Ion-Dependent Adhesion Sites in Integrins.

Density functional theory and a polarizable continuum model are used to (i) understand the affinity modulating mechanisms of the interaction between the metal-ion-dependent adhesion site (MIDAS) of a selected integrin, lymphocyte function-associated antigen-1 (LFA-1) and a ligand mimetic acetate mol...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 128; no. 11; pp. 3554 - 3564
Main Authors:	San Sebastian, Eider, Mercero, Jose M., Stote, Roland H., Dejaegere, Annick, Cossio, Fernando P., Lopez, Xabier
Format:	Article
Published:	American Chemical Society 3/22/2006
Subjects:	Integrins Density functionals Metal ions Ligands (Chemistry) Carboxylic acids Adhesion
Online Access:	View this record in EBSCOhost