Piperidines: A new class of Urease inhibitors.

A variety of piperidines (2–12, 14–26) with variable substituents at N -atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254 μM. The size and electron-donating or -withdrawin...

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Detalles Bibliográficos
Publicado en:	Natural Product Research Vol. 20; no. 6; pp. 523 - 531
Autores principales:	Mohammed Khan, Khalid, Saify, Zafar S., Arif Lodhi, Muhammad, Butt, Naeem, Perveen, Shahnaz, Murtaza Maharvi, Ghulam, Iqbal Choudhary, Muhammad, Atta-ur-rahman
Formato:	Journal Article
Publicado:	Taylor & Francis Ltd May2006
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	A variety of piperidines (2–12, 14–26) with variable substituents at N -atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254 μM. The size and electron-donating or -withdrawing effects of substituents influence the activity, which lead to the formation of urease inhibitors.