Piperidines: A new class of Urease inhibitors.

A variety of piperidines (2–12, 14–26) with variable substituents at N -atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254  μM. The size and electron-donating or -withdrawin...

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Publicado en:Natural Product Research Vol. 20; no. 6; pp. 523 - 531
Autores principales: Mohammed Khan, Khalid, Saify, Zafar S., Arif Lodhi, Muhammad, Butt, Naeem, Perveen, Shahnaz, Murtaza Maharvi, Ghulam, Iqbal Choudhary, Muhammad, Atta-ur-rahman
Formato: Journal Article
Publicado: Taylor & Francis Ltd May2006
Acceso en línea:Ver este registro en EBSCOhost
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          Mohammed Khan, Khalid
          Saify, Zafar S.
          Arif Lodhi, Muhammad
          Butt, Naeem
          Perveen, Shahnaz
          Murtaza Maharvi, Ghulam
          Iqbal Choudhary, Muhammad
          Atta-ur-rahman
        affil: H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan
      sug:
      ab: A variety of piperidines (2–12, 14–26) with variable substituents at N -atoms have been synthesized and evaluated as urease inhibitors. The synthesized compounds showed varying degree of urease inhibitory activity ranging from 31.97 to 254  μM. The size and electron-donating or -withdrawing effects of substituents influence the activity, which lead to the formation of urease inhibitors.
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      doctype: Journal Article
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    language: English
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