Cell-Permeable Peptide Nucleic Acid Designed to Bind to the 5′-Untranslated Region of E-cadherin Transcript Induces Potent and Sequence-Specific Antisense Effects.

Establishing a general and effective method for regulating gene expression in mammalian systems is important for many aspects of biological and biomedical research. Herein we report the antisense activities of a cell-permeable, guanidine-based peptide nucleic acid (PNA) called GPNA. We show that a G...

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Detalles Bibliográficos

Publicado en:	Journal of the American Chemical Society Vol. 128; no. 50; pp. 16104 - 16113
Autores principales:	Dragulescu-Andrasi, Anca, Rapireddy, Srinivas, He, Gaofei, Bhattacharya, Birendra, Hyldig-Nielsen, Jens J., Zon, Gerald, Ly, Danith H.
Formato:	Artículo
Publicado:	American Chemical Society 12/20/2006
Materias:	Gene expression Mammal cytology Peptides Proteins Antisense nucleic acids Guanidine Oligomers Biochemical research
Acceso en línea:	Ver este registro en EBSCOhost