Generation and Reactions of o-Bromophenyllithium without Benzyne Formation Using a Microreactor.

The article examines the reaction of o-Bromophenyllithium without benzyne formation using a microreactor. It is noted that an efficient way of controlling the generations and reactions of highly reactive intermediates can be accomplished by virtue of precise residence time control and temperature co...

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Detalles Bibliográficos
Publicado en:	Journal of the American Chemical Society Vol. 129; no. 11; pp. 3046 - 3048
Autores principales:	Usutani, Hirotsugu, Tomida, Yutaka, Nagaki, Aiichiro, Okamoto, Hideho, Nokami, Toshiki, Yoshida, Jun-ichi
Formato:	Artículo
Publicado:	American Chemical Society 3/21/2007
Materias:	Intermediates (Chemistry) Microreactors Temperature control Lithium Temperature
Acceso en línea:	Ver este registro en EBSCOhost

Descripción
Sumario:	The article examines the reaction of o-Bromophenyllithium without benzyne formation using a microreactor. It is noted that an efficient way of controlling the generations and reactions of highly reactive intermediates can be accomplished by virtue of precise residence time control and temperature control inherent in microsystems. The microflow systems server as a powerful tool for mechanistic studies on reactions involving highly unstable intermediates such as o-bromophenyllithium.