Discovery, Characterization, and Optimization of an Unnatural Base Pair for Expansion of the Genetic Alphabet.

DNA is inherently limited by its four natural nucleotides. Efforts to expand the genetic alphabet, by addition of an unnatural base pair, promise to expand the biotechnological applications available for DNA as well as to be an essential first step toward expansion of the genetic code. We have condu...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 130; no. 7; pp. 2336 - 2344
Main Authors:	Leconte, Aaron M., Gil Tae Hwang, Matsuda, Shigeo, Capek, Petr, Han, Yoshiyuki, Romesberg, Floyd E.
Format:	Article
Published:	American Chemical Society 2/20/2008
Subjects:	Genes Genetic code Nucleotide analysis DNA polymerases Nucleotide sequence Biotechnology
Online Access:	View this record in EBSCOhost