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Synthesis of Fluorine-18 Functionalized Nanoparticles for use as in vivo Molecular Imaging Agents.

The article reports on the study of the synthesis of fluorine-18 nanoparticles as vivo molecular imaging agents. It aims to examine the limits of enhanced permeability and retention effect (EPR effect) and to determine the possible nanoparticle size for tumor targeting. It also uses the ring opening...

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Publicado en:Journal of the American Chemical Society Vol. 130; no. 21; pp. 6731 - 6734
Autores principales: Matson, John B., Grubbs, Robert H.
Formato: Artículo
Publicado: American Chemical Society 5/28/2008
Materias:
Fluorine
Nanoparticles
Imaging systems
Polymerization
Ring-opening polymerization
Chemical reactions
Acceso en línea:Ver este registro en EBSCOhost
Sumario:The article reports on the study of the synthesis of fluorine-18 nanoparticles as vivo molecular imaging agents. It aims to examine the limits of enhanced permeability and retention effect (EPR effect) and to determine the possible nanoparticle size for tumor targeting. It also uses the ring opening metathesis polymerization (ROMP) to produce low polydispersity amphiphilic block copolymers of the cinnamoyl group.