On the Effect of Low-Energy Electron Induced DNA Strand Break in Aqueous Solution: A Theoretical Study Indicating Guanine as a Weak Link in DNA.
The article presents a study which reveals that low-energy electron (LEEs) particularly attached to guanine nucleotides can induce strand breaks in aqueous solution as showed by the results of the density functional theory (DFT) calculations of the researchers. It notes that LEEs induced low activat...
| Publicado en: | Journal of the American Chemical Society Vol. 130; no. 37; pp. 12254 - 12256 |
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| Autores principales: | , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
9/17/2008
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |
| Sumario: | The article presents a study which reveals that low-energy electron (LEEs) particularly attached to guanine nucleotides can induce strand breaks in aqueous solution as showed by the results of the density functional theory (DFT) calculations of the researchers. It notes that LEEs induced low activation energies for the phosphodiester bond rupture in both gas phase and aqueous solution. Also, DNA strand breaks would likely to occur when a LEE is attached to the guanine nucleotide. |
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