On the Effect of Low-Energy Electron Induced DNA Strand Break in Aqueous Solution: A Theoretical Study Indicating Guanine as a Weak Link in DNA.
The article presents a study which reveals that low-energy electron (LEEs) particularly attached to guanine nucleotides can induce strand breaks in aqueous solution as showed by the results of the density functional theory (DFT) calculations of the researchers. It notes that LEEs induced low activat...
| Publicado en: | Journal of the American Chemical Society Vol. 130; no. 37; pp. 12254 - 12256 |
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| Autores principales: | , |
| Formato: | Artículo |
| Publicado: |
American Chemical Society
9/17/2008
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| Acceso en línea: | Ver este registro en EBSCOhost |
| fields | @attributes: recordID: 1 pdfLink: plink: https://search.ebscohost.com/login.aspx?direct=true&db=hlh&AN=34543278&site=ehost-live header: @attributes: shortDbName: hlh uiTerm: 34543278 longDbName: Humanities International Complete uiTag: AN controlInfo: bkinfo: jinfo: jid: 00027863 ACS jtl: Journal of the American Chemical Society issn: 00027863 maglogo: N pubinfo: dt: 9/17/2008 vid: 130 iid: 37 pid: 997 pub: American Chemical Society artinfo: ui: 34543278 10.1021/ja805000g ppf: 12254 ppct: 2 formats: tig: atl: On the Effect of Low-Energy Electron Induced DNA Strand Break in Aqueous Solution: A Theoretical Study Indicating Guanine as a Weak Link in DNA. aug: au: Schyman, Patric Laaksonen, Aatto affil: Division of Physical Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden su: Electrons Nucleotides Density functionals Solution (Chemistry) Phosphodiesters DNA Physical & theoretical chemistry sug: subj: Electrons Nucleotides Density functionals Solution (Chemistry) Phosphodiesters DNA Physical & theoretical chemistry ab: The article presents a study which reveals that low-energy electron (LEEs) particularly attached to guanine nucleotides can induce strand breaks in aqueous solution as showed by the results of the density functional theory (DFT) calculations of the researchers. It notes that LEEs induced low activation energies for the phosphodiester bond rupture in both gas phase and aqueous solution. Also, DNA strand breaks would likely to occur when a LEE is attached to the guanine nucleotide. pubtype: Academic Journal doctype: Article src: R language: English refInfo: copyright: @attributes: flag: Y dt: @attributes: year: 2008 holdings: @attributes: islocal: N |
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