Is the Bound Substrate in Nitric Oxide Synthase Protonated or Neutral and What Is the Active Oxidant that Performs Substrate Hydroxylation?

We present here results of a series of density functional theory (DFT) studies on enzyme active site models of nitric oxide synthase (NOS) and address the key steps in the catalytic cycle whereby the substrate (L-arginine) is hydroxylated to N-hydroxo-arginine. It has been proposed that the mechanis...

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Detalles Bibliográficos

Publicado en:	Journal of the American Chemical Society Vol. 130; no. 39; pp. 12961 - 12975
Autores principales:	de Visser, Sam P., Lee Siew Tan
Formato:	Bibliografía
Publicado:	American Chemical Society 10/1/2008
Materias:	Density functionals Enzymes Nitric oxide Reactive oxygen species Catalysis Protons
Acceso en línea:	Ver este registro en EBSCOhost