Is the Bound Substrate in Nitric Oxide Synthase Protonated or Neutral and What Is the Active Oxidant that Performs Substrate Hydroxylation?
We present here results of a series of density functional theory (DFT) studies on enzyme active site models of nitric oxide synthase (NOS) and address the key steps in the catalytic cycle whereby the substrate (L-arginine) is hydroxylated to N-hydroxo-arginine. It has been proposed that the mechanis...
| Publicado en: | Journal of the American Chemical Society Vol. 130; no. 39; pp. 12961 - 12975 |
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| Autores principales: | , |
| Formato: | Bibliografía |
| Publicado: |
American Chemical Society
10/1/2008
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| Materias: | |
| Acceso en línea: | Ver este registro en EBSCOhost |