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Polymorphism of a Hexa-host: Isolation of Four Different Single-Crystal Phases by Melt Crystallization.

The article reports on isolation of a hexa-host compound which yields several polymorphic forms with different single-crystal phases using melt crystallization. Polymorphism is the existence of several different kinds of crystal on the same chemical substance in the crystalline solid state. Polymorp...

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Published in:Journal of the American Chemical Society Vol. 130; no. 43; pp. 14032 - 14034
Main Authors: Das, Dinabandhu, Barbour, Leonard J.
Format: Article
Published: American Chemical Society 10/29/2008
Subjects:
Polymorphism (Crystallography)
Crystallization
Optical diffraction
Crystal growth
Online Access:View this record in EBSCOhost
Summary:The article reports on isolation of a hexa-host compound which yields several polymorphic forms with different single-crystal phases using melt crystallization. Polymorphism is the existence of several different kinds of crystal on the same chemical substance in the crystalline solid state. Polymorphs adversely affect the desired formulation of a product in pharmaceutical and chemical industry; thus, single-crystal diffraction (SCD) for characterization will be used.