Modeling Differential Binding of α4β2 Nicotinic Acetyicholine Receptor with Agonists and Antagonists.

Three-dimensional structures of both the open- and closed-channel states of α4β2 receptor have been modeled and used to study their binding with representative agonists and antagonists. The obtained binding structures and free energies consistently reveal that antagonists bind more favorably with th...

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Publicado en:	Journal of the American Chemical Society Vol. 130; no. 49; pp. 16691 - 16697
Autores principales:	Xiaoqin Huang, Fang Zheng, Chang-Guo Zhan
Formato:	Artículo
Publicado:	American Chemical Society 12/10/2008
Materias:	Computer network protocols Ligand binding (Biochemistry) Nicotinic receptors Chemical inhibitors Chemical agonists Biochemistry Therapeutics
Acceso en línea:	Ver este registro en EBSCOhost