Modeling Differential Binding of α4β2 Nicotinic Acetyicholine Receptor with Agonists and Antagonists.

Three-dimensional structures of both the open- and closed-channel states of α4β2 receptor have been modeled and used to study their binding with representative agonists and antagonists. The obtained binding structures and free energies consistently reveal that antagonists bind more favorably with th...

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Bibliographic Details

Published in:	Journal of the American Chemical Society Vol. 130; no. 49; pp. 16691 - 16697
Main Authors:	Xiaoqin Huang, Fang Zheng, Chang-Guo Zhan
Format:	Article
Published:	American Chemical Society 12/10/2008
Subjects:	Computer network protocols Ligand binding (Biochemistry) Nicotinic receptors Chemical inhibitors Chemical agonists Biochemistry Therapeutics
Online Access:	View this record in EBSCOhost