ILPR G-Quadruplexes Formed in Seconds Demonstrate High Mechanical Stabilities.

The insulin linked polymorphism region (ILPR) is known to regulate transcription of the gene coding for insulin. The ILPR has guanine rich segments, suggesting that G quadruplexes may be responsible for this regulatory role. Using mechanical unfolding in a laser tweezers instrument and circular dich...

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Detalles Bibliográficos

Publicado en:	Journal of the American Chemical Society Vol. 131; no. 5; pp. 1876 - 1883
Autores principales:	Zhongbo Yu, Schonhoft, Joseph O., Dhakal, Soma, Bajracharya, Rabindra, Hegde, Ravi, Basu, Soumitra, Mao, Hanbin
Formato:	Artículo
Publicado:	American Chemical Society 2/11/2009
Materias:	Genetic transcription Genetic code Insulin Quadruplex nucleic acids Hypoglycemic agents Spectrum analysis
Acceso en línea:	Ver este registro en EBSCOhost